Customizing continuous chemistry and catalytic conversion for carbon–carbon cross-coupling with 3dP

Abstract Support structures of various materials are used to enhance the performance catalytic process chemistry. Typically, fixed bed supports contain regular channels enabling high throughput because low pressure drop that accompanies flow rates. However, many have a surface-area-to-volume ratio resulting in poor contact between substrates and catalyst. Three dimensional polymer printing (3dP) can be overcome these disadvantages by offering precise control over key design parameters bed, including total surface area, as well accommodating system integration features compatible with continuous Additionally, 3dP allows for optimization based on extrinsic constraints (e.g. operating pressure) digital features. These together physicochemical characterization catalyst loading tuned prepare customizable reactors objectives substrate conversion desired throughput. Using Suzuki (carbon–carbon) cross-coupling reaction catalyzed palladium, we demonstrate our integrated approach. We discuss elements strategy rational hydrodynamics, immobilization heterogeneous catalyst, conversion. This hybrid digital-physical approach enables range pharmaceutical chemistries spanning discovery manufacturing scale.